There are no known contraindications. However, collagen may not be suitable for people who:
- Sensitive to histamine
- Affected by hyperoxaluria

INSTAMINE

Those with histamine sensitivity may experience side effects. Collagen tolerance is highly individual: some people with histamine intolerance have no issues, while others may react.

If you have a histamine-related food sensitivity or mast cell activation syndrome (a more severe and clinically recognized condition), you may need to avoid collagen, gelatin, bone broth, fermented vegetables, and seasoned foods, depending on your individual tolerance.

If you have problems with histamine, I recommend the following. READ MORE Of functional physician Dr. Lorenzo Toccacieli.

SECONDARY HYPEROXALURIA

Only individuals with this type of condition might experience problems when taking collagen or gelatin, we use the conditional because there is currently no conclusive evidence. This is due to the fact that some hydroxyproline and glycine may be converted into calcium oxalate.

Oxalates can contribute to calcium oxalate stone formation only in patients with secondary hyperoxaluria. For all other individuals who have calcium oxalate stones but not hyperoxaluria, the general recommendation is simply to reduce foods that are particularly high in oxalates โ€” such as beets, spinach, and tomatoes. Once these are removed, there is little evidence linking moderate oxalate intake to an increased risk of stone formation. Instead, dehydration, low citrate levels, metabolic syndrome, and genetic predisposition are currently considered the main factors associated with kidney stone development.

Today it is estimated that calcium oxalates excreted with urine result from: (total does not make 100% because these are estimates, not certainties)
- For about 50% from the oxalates in the food we consume (1)
- For about 40% from ascorbic acid or ascorbate (vitamin C). In people predisposed to stone formation, it appears that ascorbic acid may contribute even more, up to 80%, to the presence of oxalates in urine. (2)
- For about 15% from hydroxyproline (1)
- For less than 5% from glycine (1)

Collagen and gelatin contain glycine and hydroxyproline

If you have problems with kidney stones you might find it helpful to look at this live with Dr. Francesca Manfra, functional physician, In which we talked about what causes kidney stones and what can be done to decrease their formation. In the first 20 minutes, Dr. Manfra explains in detail why collagen is NOT one of the causes of kidney stones.